Indications of abortion are different country by country, also in Islamic ones. The aim of this paper is over viewing of legal and religious indications of safe abortion among Middle East, Muslim countries. The results showed the variation among countries. In such a manner that, only three countries have the legal abortion in cases of rape or fatal impairment and two of them are allowing for early abortion. Some health problems in six countries in this case, permit for abortion. In certain situations, religious fatawa have been allowed abortions. Evaluation the interaction between policies and religion among different Muslim countries is important to understand this variation. To increasing women’s right would be done more research and efforts. To impress and explain communities and religious leaders might be effective. Promoting advocacy among health professional could be other efforts to change the different beliefs among Muslim countries and others.