Introduction: Brain death and organ donation are important issues. Problems involving logistics, ethical issues, personal resistance, and legal difficulties will probably always limit the number of available donors.The aim of this article to review brain death and organ donation and various factors related to success of this in IRAN.

Method: A systemic review was performed. We searched the pub med, Cochran are embays date base form 1995 to 2010, and the date published in Persian journal in IRAN from 1365 to 1389, all studies reporting brain death and organ donation and related factors.

Result: Organ donation is about 1/7 per million in IRAN and very fewer of Europe and American country. The mean age of organ donation was 25/6 years old. Various factors related to success of organ Transplantation in IRAN include: Positive attitude of public towards organ donation, consent by relations for organ donation and support logistics, knowledge, motivation and self- confidence nurse and physician towards organ donation, and religious views on organ donation.

Conclusion: Brain death and organ donation are difficult decision, for public, physician and family. We recommended people had signed a donor volunteered card in live time.